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MyBioSource/Pigeon A Disintegrin and Metalloprotease 10 ELISA Kit/MBS059150/5x96-Strip-Wells

MyBioSource/Pigeon A Disintegrin and Metalloprotease 10 ELISA Kit/MBS059150/5x96-Strip-Wells
  • MyBioSource/Pigeon A Disintegrin and Metalloprotease 10 ELISA Kit/MBS059150/5x96-Strip-Wells
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COVID-19一站式试剂店-MyBioSourceCOVID-19 / SARS-CoV-2 研究试剂的领先来源我们的产品组合每天更新,包括IgG / IgM血清学抗体测定, PCR 试剂人源化抗体和传统抗体重组蛋白 等。选择即用型COVID-19产品或散装原料,构建自己的PCR检测, 免疫测定快速检测在MyBioSource科学平台上以超过200万种生命科学产品的高性价比,一站式购物方式满足您所有的COVID-19研究需求。

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MyBioSource可以生产用于多种靶标和物种的ELISA试剂盒。如果找不到所需的目标和/或物种,请提交请求。也可以定制ELISA试剂盒生产。套件可以根据用户的规格进行设计和生产。 学到更多...

定制蛋白质和
抗体生产

MyBioSource可以适应重组蛋白的需求。我们提供在大肠杆菌,酵母,杆状病毒或哺乳动物细胞宿主中表达的灵活性。蛋白质是在温和的条件下产生的,以避免活性损失。我们还是抗原亲和纯化多克隆抗体的专家,并且在过去的十年中我们的工艺得到了优化。 学到更多...

全球各地的研究人员都在使用 MyBioSource的Zika病毒ELISA试剂盒Zika病毒PCR试剂盒来研究ZIKV

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  • ELISA试剂盒

    ELISA(酶联免疫吸附测定)是使用湿实验室生物化学技术检测特定物质存在的一种流行格式。  阅读更多

  • 单克隆抗体

    使用与骨髓瘤细胞融合的免疫细胞产生单克隆抗体,并且产生的杂交瘤产生与特定表位结合的独特克隆。  阅读更多

  • 多克隆抗体

    多克隆抗体提供了可靠的检测方法,可用于鉴定与用作免疫原的蛋白质具有高度同源性的蛋白质。  阅读更多

  • 多克隆和单克隆抗体的主要区别

    多克隆抗体是通过向宿主物种注射免疫原而产生的。  阅读更多

  • 重组/纯化蛋白

    为了正确表征蛋白质的结构和功能,以及它们之间的相互作用,通常有必要纯化目标蛋白质。  阅读更多

  • 二抗

    虽然一抗直接与目标蛋白结合,但是二抗主要用于免疫标记。  阅读更多

  • 肽类

    肽由通过胺键连接在一起的氨基酸短链组成。  阅读更多

  • 配体结合测定

    在进行配体结合测定时,重要的是使用高度敏感和特异的试剂盒以产生准确的结果。  阅读更多

研究热点

COVID-19新型冠状病毒2019-nCoV的正式名称

世界卫生组织(WHO)于2月11日将COVID-19命名为新型冠状病毒2019-nCoV的正式名称...

您需要了解的冠状病毒

2019年12月下旬,中国湖北省武汉市爆发了一次神秘的肺炎,导致发现了一个新的肺炎。

传染性海绵状脑病(TSE)

蛋白质错误折叠疾病中的ions病毒和类似on病毒的蛋白质on病毒和病毒样蛋白质越来越被认为是...

基因编辑技术:HIV

基因编辑技术在HIV研究中显示出无穷前景用于编辑基因的CRISPR / Cas系统的开发正在彻底改变...

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许多人认为骨质疏松症是一种主要影响妇女的疾病,尤其是老年或绝经后妇女。但是...

疟疾-您需要知道什么?

疟疾感染推动基因突变整合到人类基因组中疟疾是由Pl引起的一种传染性疾病。

ALS(肌萎缩性侧索硬化症)

控制肌肉的神经元的变性和最终死亡是肌萎缩性侧索硬化症(ALS)的标志,这是一种罕见的...

阿尔茨海默氏病及其症状的7个阶段

痴呆症最常见的病因是阿尔茨海默氏病,以德国精神病医生和神经科医师Aloysius Alzheimer博士的名字命名。

您应该了解人类乳头瘤病毒(HPV)?

令人讨厌的国家和蓝草歌手兼作词人乔伊·菲克(Joey Feek)从宫颈癌去世了...

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 ProductName  ADisintegrinandMetalloprotease10(ADAM10),ELISAKit
 AlsoKnownAs  PigeonADisintegrinandMetalloprotease10ELISAKit
 ProductGeneName  ADAM10elisakit[SimilarProducts]
 ResearchUseOnly  ForResearchUseOnly.Notforuseindiagnosticprocedures.
 RequestforManualInsert  Request Manual
 ChromosomeLocation  Chromosome:15;NC_000015.9(58888510..59042177,complement).Location:15q22
 OMIM  602192
 3DStructure  ModBase3DStructureforO14672
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 SpeciesReactivity  Pigeon
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 PreparationandStorage  Storeallreagentsat2-8degreeC
 ProductNote  OurELISAassaysaredynamicresearchtoolsandsometimestheymaybeupdatedandimproved.Iftheformatofthisassayisimportanttoyouthenpleasecontactourtechnicalsupportteamwithapresalesinquirybeforeplacinganorder.Wewillconfirmthecurrentdetailsoftheassay.
 OtherNotes  SmallvolumesofADAM10elisakitvial(s)mayoccasionallybecomeentrappedinthesealoftheproductvialduringshipmentandstorage.Ifnecessary,brieflycentrifugethevialonatabletopcentrifugetodislodgeanyliquidinthecontainer`scap.Certainproductsmayrequiretoshipwithdryiceandadditionaldryicefeemayapply.
 SearchableTermsforADAM10purchase  MBS059150isaready-to-usemicrowell,stripplateELISA(enzyme-linkedimmunosorbentassay)KitforanalyzingthepresenceoftheADisintegrinandMetalloprotease10(ADAM10)ELISAKittargetanalytesinBIOLOGicalsamples.TheconcentrationgrADIentsofthekitstandardsorpositivecontrolsrenderatheoreticalkitdetectionrangeinbiologicalresearchsamplescontainingADAM10.TheELISAanalyticalbiochemicaltechniqueoftheMBS059150kitisbasedonADAM10antibody-ADAM10antigeninteractions(immunosorbency)andanHRPcolorimetricdetectionsystemtodetectADAM10antigentargetsinsamples.TheELISAKitisdesignedtodetectnative,notrecombinant,ADAM10.Appropriatesampletypesmayincludeundilutedbodyfluidsand/ortissuehomogenates,secretions.Qualitycontrolassaysassessingreproducibilityidentifiedtheintra-assayCV(%)andinter-assayCV(%).
NCBI/UniprotdatabelowdescribegeneralgeneinformationforADAM10.Itmaynotnecessarilybeapplicabletothisproduct.
 NCBIGI#  2393947
 NCBIGeneID  102
 NCBIAccession#  AAC51766.1[OtherProducts]
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 UniProtPrimaryAccession#  O14672[OtherProducts]
 UniProtSecondaryAccession#  Q10742;Q92650[OtherProducts]
 UniProtRelatedAccession#  O14672[OtherProducts]
 MolecularWeight  84,142Da
 NCBIOfficialFullName  ADAM10
 NCBIOfficialSynonymFullNames  ADAMmetallopeptidasedomain10
 NCBIOfficialSymbol  ADAM10[SimilarProducts]
 NCBIOfficialSynonymSymbols  
kuz;AD10;MADM;CD156c;HsT18717
[SimilarProducts]
 NCBIProteinInformation  disintegrinandmetalloproteinasedomain-containingprotein10;CDw156;ADAM10;kuzbanianproteinhomolog;mammaliandisintegrin-metalloprotease;adisintegrinandmetalloproteasedomain10;adisintegrinandmetalloproteinasedomain10
 UniProtProteinName  Disintegrinandmetalloproteinasedomain-containingprotein10
 UniProtSynonymProteinNames  
CDw156;Kuzbanianproteinhomolog;Mammaliandisintegrin-metalloprotease
 ProteinFamily  Disintegrinandmetalloproteinasedomain-containingprotein
 UniProtGeneName  ADAM10[SimilarProducts]
 UniProtSynonymGeneNames  KUZ;MADM;ADAM10[SimilarProducts]
 UniProtEntryName  ADA10_HUMAN
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 NCBISummaryforADAM10  MembersoftheADAMfamilyarecellsurfaceproteinswithauniquestructurepossessingbothpotentialadhesionandproteasedomains.ThisgeneencodesandADAMfamilymemberthatcleavesmanyproteinsincludingTNF-alphaandE-cadherin.[providedbyRefSeq,Jul2008]
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 UniProtCommentsforADAM10  ADAM10:Cleavesthemembrane-boundprecursorofTNF-alphaat'76-Ala-|-Val-77'toitsmaturesolubleform.ResponsIBLefortheproteolyticalreleaseofsolubleJAM3fromendothelialcellssurface.Responsiblefortheproteolyticreleaseofseveralothercell-surfaceproteins,includingheparin-bindingepidermalgrowth-likefactor,ephrin-A2andforconstitutiveandregulatedalpha-secretasecleavageofamyloidprecursorprotein(APP).Contributestothenormalcleavageofthecellularprionprotein.InvolvedinthecleavageoftheadhesionmoleculeL1atthecellsurfaceandinreleasedmembranevesicles,suggestingavesicle-basedproteaseactivity.ControlsalsotheproteolyticprocessingofNotchandmediateslateralinhibitionduringneurogenesis.ResponsiblefortheFasLectodomainsheddingandforthegenerationoftheremnantADAM10-processedFasL(FasLAPL)transmembraneform.AlsocleavestheectodomainoftheintegralmembraneproteinsCORINandITM2B.MayregulatetheEFNA5-EPHA3signaling.

Proteintype:Vesicle;Protease;Membraneprotein,integral;Cellsurface;Celladhesion;Motility/polarity/chemotaxis;EC3.4.24.81

ChromosomalLocationofHumanOrtholog:15q22

CellularComponent:Golgiapparatus;cellsurface;focaladhesion;membrane;intracellularmembrane-boundorganelle;postsynapticdensity;cytoplasm;integraltomembrane;plasmamembrane;Golgi-associatedvesicle;nucleus

MolecularFunction:integrinbinding;proteinbinding;proteinhomodimerizationactivity;metallopeptidaseactivity;zincionbinding;metalloendopeptidaseactivity;endopeptidaseactivity;SH3domainbinding;proteinkinasebinding;receptorbinding

BiologicalProcess:integrin-mediatedsignalingpathway;epidermalgrowthfactorreceptorsignalingpathway;axonguidance;Notchsignalingpathway;extracellularmatrixorganizationandbiogenesis;inuteroembryonicdevelopment;constitutiveproteinectodomainproteolysis;membraneproteinectodomainproteolysis;Notchreceptorprocessing;negativeregulationofcelladhesion;proteinaminoacidphosphorylation;positiveregulationofcellgrowth;collagencatabolicprocess;extracellularmatrixdisassembly;PMA-induciblemembraneproteinectodomainproteolysis;cell-cellsignaling;monocyteactivation;positiveregulationofcellproliferation;ephrinreceptorsignalingpathway;positiveregulationofcellmigration

Disease:ReticulateAcropigmentationOfKitamura;AlzheimerDisease18
 ResearchArticlesonADAM10  1.MiR-144andMir-451negativelyregulatortheADAM10proteinexpressionandmaycontributetoAlzheimerdiseasepathogenesis.
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